Abstract

Case Report

Cystic Micronodular Thymoma. Report of a Case

Mona Mlika*, Adel Marghli and Faouzi Mezni

Published: 20 January, 2017 | Volume 1 - Issue 1 | Pages: 001-004

Micronodular thymoma is a rare subtype of thymoma with less than 20 cases published in the English literature. These tumours have been reported with thymoma or thymic cyst. The authors describe a new case of micronodular thymoma in a 68-year-old-patient which is well documented and particular by its cystic degeneration which hasn’t been described yet. Micronodular thymoma is a rare variant of thymoma with a challenging diagnosis. Clinicians must be aware of this entity in order not to confuse it with a thymic cyst.

Read Full Article HTML DOI: 10.29328/journal.jcmei.1001001 Cite this Article Read Full Article PDF

Keywords:

Diagnosis; Pathology; Thymoma

References

  1. Marx A, Chan JK, Coindre JM, Detterbeck F, Girard N, et al. The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. J Thorac Oncol. 2015; 10: 1383-1395. Ref.: https://goo.gl/xA01c1
  2. Nakamura S, Tateyama H, Taniguchi T, Ishikawa Y, Kawaguchi K, et al. Multilocular Thymic Cyst Associated With Thymoma. A Clinicopathologic Study of 20 Cases With an Emphasis on the Pathogenesis of Cyst Formation. Am J Surg Pathol. 2012; 36: 1857-1864. Ref.: https://goo.gl/W0MJrd
  3. Marx A, Ströbel Ph, Marino M, Eimoto T, Harris NL, et al. Tumours of the thymus-Thymomas. Chapter 3. Micronodular thymoma with lymphoid stroma. 167-168.
  4. Suster S, Moran CA. Micronodular thymoma with lymphoid B-cell hyperplasia. clinicopathologic and immunohistochemical study of eighteen cases of a distinctive morphologic variant of thymic epithelial neoplasm. Am J Surg Pathol. 1999; 23: 955-962. Ref.: https://goo.gl/87Zfas
  5. Suster S, Rosai J. Cystic thymomas. A clinicopathlogic study of ten cases. Cancer. 1992; 69: 92-97. Ref.: https://goo.gl/fpt38W
  6. Planelles A, Aranda FI, Córdoba C, Aboumar A, Payá A. Micronodular thymoma with lymphoid B-cell hyperplasia. Report of a case. Rev Esp Patol. 2007; 40: 113-116.
  7. Strobel P, Marino M, Feuchtenberger M, Rouzière AS, Tony HP, et al. Micronodular thymoma. an epithelial tumour with abnormal chemokine expression setting the stage for lumphoma development. J Pathol. 2005; 207: 72-82. Ref.: https://goo.gl/o2YLMH
  8. Tateyama H, Saito Y, Fujii Y, Okumura M, Nakamura K, et al. The spectrum of micronodular thymic epithelial tumours with lymphoid B-cell hyperplasia. Histopathology. 2001; 38: 519-527. Ref.: https://goo.gl/Xbyl9V
  9. Zhu P, Yan F, Ao Q. Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report. Int J Clin Exp Pathol. 2014; 7: 7262-7267. Ref.: https://goo.gl/21Elhb
  10. Chen CW, Chuang SS, Pan ST. Micronodular Thymoma with Lymphoid Stroma Diagnosed with Core Needle Biopsy. A Case Report. Anal Quant Cytopathol Histpathol. 2015; 37: 206-210. Ref.: https://goo.gl/YtLZUm
  11. Cha YJ, Han J, Kim J, Lee KS, Shim YM. A rare case of mixed type a thymoma and micronodular thymoma with lymphoid stroma. J Pathol Transl Med. 2015; 49: 75-77. Ref.: https://goo.gl/4jCr2z
  12. Kim NR, Lee JI, Ha SY. Micronodular thymoma with lymphoid stroma in a multilocular thymic cyst: a case study. Korean J Pathol. 2013; 47: 392-394. Ref.: https://goo.gl/4pp4I4

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

  • SARS-CoV-2 antibody response to third dose vaccination in a healthy cohort
    Simmi Patel*, Sarah E Wheeler, Adam Anderson, Lisa Pinto and Michael R Shurin Simmi Patel*,Sarah E Wheeler,Adam Anderson,Lisa Pinto,Michael R Shurin. SARS-CoV-2 antibody response to third dose vaccination in a healthy cohort. Insights Clin Cell Immunol. 2022: doi: 10.29328/journal.icci.1001020; 6: 008-013
  • Application of In vitro Reconstructed 3D Biomimetic Tumor Microenvironment Models in Cancer Research
    Yinuo Ma, Zhiyuan Lu, Yili Sun and Jia Li Yinuo Ma,Zhiyuan Lu,Yili Sun,Jia Li. Application of In vitro Reconstructed 3D Biomimetic Tumor Microenvironment Models in Cancer Research. Arch Cancer Sci Ther. 2026: doi: 10.29328/journal.acst.1001051; 10: 16-27
  • Human Poxvirus Infections: Epidemiology, Transmission, and Clinical Features of Major Orthopoxvirus Diseases
    Trisha Chakraborty, Naima Siddiqua, Subrin Shabab Trisa, Syeda Fatima Anwar and Gazi Wafa Akbar* Trisha Chakraborty,Naima Siddiqua,Subrin Shabab Trisa,Syeda Fatima Anwar,Gazi Wafa Akbar*. Human Poxvirus Infections: Epidemiology, Transmission, and Clinical Features of Major Orthopoxvirus Diseases. Int J Clin Microbiol Biochem Technol. 2026: doi: 10.29328/journal.ijcmbt.1001038; 9: 34-39
  • Intravenous Leiomyomatosis of the Uterus with Intracardiac Extension
    Tomas Reyes-del Castillo*, Minerva I Hernandez-Rejon, Jose L Ruiz-Pier, Mario Peñaloza-Guadarrama, Carlos E Merinos-Avila, Cristina Juarez-Cabrera, Pedro A del Valle-Maldonado, Sofia Ley-Tapia and Valentín Gonzalez-Flores Tomas Reyes-del Castillo*,Minerva I Hernandez-Rejon,Jose L Ruiz-Pier,Mario Peñaloza-Guadarrama,Carlos E Merinos-Avila,Cristina Juarez-Cabrera,Pedro A del Valle-Maldonado,Sofia Ley-Tapia,Valentín Gonzalez-Flores. Intravenous Leiomyomatosis of the Uterus with Intracardiac Extension. Arch Vas Med. 2025: doi: 10.29328/journal.avm.1001021; 9: 003-007
  • Nasal cytology in patients with previous SARS-CoV-2 infection: occurrence of atypical lymphocytes
    Arturo Armone Caruso*, Anna Miglietta, Giovanni De Rossi, Liliana Nappi, Veronica Viola, Stefano De Rossi, Salvatore Del Prete, Clara Imperatore, Sabato Leo, Daniele Naviglio, Monica Gallo, Daniela Marasco and Lucia Grumetto Arturo Armone Caruso*, Anna Miglietta, Giovanni De Rossi, Liliana Nappi, Veronica Viola, Stefano De Rossi, Salvatore Del Prete, Clara Imperatore, Sabato Leo, Daniele Naviglio, Monica Gallo, Daniela Marasco, Lucia Grumetto. Nasal cytology in patients with previous SARS-CoV-2 infection: occurrence of atypical lymphocytes. Adv Treat ENT Disord. 2023: doi: 10.29328/journal.ated.1001014; 7: 001-006

Read More

Most Viewed

Read More

Help ?