Impact of Microplastics on Human Health through the Consumption of Seafood: A Review

Neeraj Kumar; Dev Brat Mishra

Abstract

Review Article

Impact of Microplastics on Human Health through the Consumption of Seafood: A Review

Neeraj Kumar* and Dev Brat Mishra

Published: 14 June, 2025 | Volume 9 - Issue 1 | Pages: 015-019

Microplastics (MPs) pose a significant risk to human health, particularly through seafood consumption. Once ingested, MPs can spread from the digestive system to other organs via phagocytosis and endocytosis, leading to toxicological effects. Accumulation of MPs in tissues causes swelling, blockages, oxidative stress, and Cytotoxicity. Studies show MPs alter metabolism, disrupt immune function, and contribute to autoimmune diseases. Chronic exposure has been linked to neurotoxicity, vascular inflammation, and increased cancer risk due to DNA damage. MPs can cross biological barriers, including the placenta, affecting fetal development. Additionally, they serve as vectors for pollutants and bacteria, further complicating health risks. MPs in the bloodstream can trigger inflammatory responses, endothelial adhesion, and red blood cell coagulation, leading to cardiovascular complications. In vitro studies indicate MPs impair renal function and cause long-term inflammation in distal tissues. Moreover, oxidative stress caused by MPs plays a critical role in carcinogenicity. Despite growing evidence of adverse health effects, further research is necessary to understand the full impact of MPs’ exposure on human health and develop effective mitigation strategies.

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Keywords:
Microplastics; Oxidative stress; Neurotoxicity; Cytotoxicity; Other tissues

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