Abstract

Case Report

Adult Bladder Exstrophy with Premalignant Changes Following Failed Reconstruction: A Case Report

Mohammed Amine Elafari*, Mamad Ayoub, Mohamed Amine Zaki, Mohammed Amine Bibat, Amine Slaoui, Tarik Karmouni, Abdelatif Koutani and Khalid Elkhader

Published: 01 April, 2026 | Volume 10 - Issue 1 | Pages: 020-023

Background: Bladder exstrophy is a rare congenital abnormality that is usually managed with multiple surgical interventions. Long-term consequences include recurrent urinary tract infections, bladder stones, fistulae, and metaplastic changes with malignant potential.
Case Presentation: We present a case of a 21-year-old male with a history of failed childhood surgeries for bladder exstrophy who presented with a vesicocutaneous fistula and a 7 cm bladder stone. He underwent an open cystolithotomy with bladder augmentation and creation of a Benchekroun continent valve. However, the patient developed recurrent fistulae due to poor tissue quality. Histopathological examination confirmed early squamous metaplasia in the bladder mucosa. After discussion in a multidisciplinary meeting, the patient underwent a radical cystectomy with ileal conduit urinary diversion using the Bricker technique. He is doing well at 3 months with no evidence of any complication.
Conclusion: This case illustrates the difficulties encountered in managing adult patients with bladder exstrophy and failed reconstructions. The presence of squamous metaplasia, poor bladder tissue, and recurrent complications all contributed to the decision for radical cystectomy. It is important to recognize these changes and address them appropriately in a timely manner to prevent further complications and possible malignant changes.

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Keywords:

Bladder exstrophy; Squamous metaplasia; Radical cystectomy; Ileal conduit; Vesicocutaneous fistula

References

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  • Adult Bladder Exstrophy with Premalignant Changes Following Failed Reconstruction: A Case Report
    Mohammed Amine Elafari*, Mamad Ayoub, Mohamed Amine Zaki, Mohammed Amine Bibat, Amine Slaoui, Tarik Karmouni, Abdelatif Koutani and Khalid Elkhader Mohammed Amine Elafari*,Mamad Ayoub,Mohamed Amine Zaki,Mohammed Amine Bibat,Amine Slaoui,Tarik Karmouni,Abdelatif Koutani,Khalid Elkhader. Adult Bladder Exstrophy with Premalignant Changes Following Failed Reconstruction: A Case Report. . 2026 doi: ; 10: 020-023

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